![]() ![]() ![]() Change the sharpening and contrast of the images as well as provides edge smoothening features.A variety of customizations and settings to adjust color and luminance.Works with night scenes, portraits, and algorithms for different noise types.Improve the look and feel of the images and adjust other details.Detecting the noise patterns and eliminate them automatically.A variety of presets and settings to quickly adjust the images.A comprehensive application for reducing the noise in the images.On concluding notes, Imagenomic Noiseware 2021 is a comprehensive photoshop plugin that allows the users to reduce the level of noise and adjust the images. All the changes are implemented in real-time and the users can preview the changes within the application. In addition, it is also possible to sharpen the images and contrast level along with edge smoothening. Moreover, it is also possible to adjust the noise level in the shadows and produce high-quality results with great ease. You can also download Imagenomic Portraiture 3.5.2 Customize the luminance and the color levels of the images and provides a comprehensive set of tools for producing accurate and realistic results. It provides a variety of configurations and settings that allows the users to work with night scenes, landscapes, portraits, and other types of images. This powerful application comes with auto-mode and provides a complete solution for reaching better results. This powerful application provides automatic denoising features with presets and provides a variety of powerful algorithms to process the images. It is a very lightweight plugin with seamless integration with Adobe Photoshop and delivers maximum productivity. It provides a simple and straightforward user interface that allows the users to perform all the operations for processing the images and provides a comprehensive solution for improving the look and feel of the digital images. Imagenomic Noiseware 5 OverviewĪ comprehensive Photoshop Plugin, Imagenomic Noiseware 5.1.2 comes with a variety of options and features for removing noise from the image collections. Noiseware is a powerful Photoshop plugin for removing noise from photo collections and make the images smoother and appealing. Download Imagenomic Noiseware 5 latest full version offline complete setup for Windows.
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If you are looking for the best activities on the Big Island, look no further. The water clarity is stunning and the bay is blissfully calm. ![]() ![]() Embark on an unforgettable Snorkel and Dolphin Cruise to the Captain Cook Monument on the Big Island! Call ahead and we'll have your kayak or paddle board ready for you. Kealakekua Bay is the largest deep water bay in Hawaii. Captain Cook side better with nice reefs and lots of fish. It is named after Captain Cook, the circumnavigator who landed here in January 1779 and was killed a month later. Search This time around, the Hawaiians took one of the ship's small boats, called cutters. What to Know Before You Go to the Big Island. Drew Gregory won the 2022 Yamaha Rightwaters Bassmaster Kayak Series at Grand Lake powered by TourneyX with a five-bass fish limit of 91.5 inches, according to a news release from the Bass Anglers Sportsman Society, or B.A.S.S. Kealakekua is also a State Historical Park that marks the location of the first significant contact between Hawaiians and westerners. But, if the idea of a hike and snorkel DIY day sounds good to you, that is sure to turn out to be a GREAT Big Island day too! This is the only kayak rental business at Kealakekua Bay. Restaurants près de Ka'awa Loa Plantation sur Tripadvisor : consultez 6 402 avis et 3 635 photos de voyageurs pour connaître les meilleures tables près de Ka'awa Loa Plantation à Captain Cook, Hawaï. Kealakekua Bay and Captain Cook - Jon the Road Again. RELATED: 15 Things to Do on the Big Island. This terrific two-person inflatable kayak comes with seats (adjustable, removable), paddles, inflation/deflation pump, removable scupper fin, storage bag and is permitted for Kealakekua Bay. He anchored his bag with a 20.25-inch bass, beating second-place angler Daniel Maffei by more than 8 inches. Big Island of Hawaii, HawaiiGuided Outrigger Canoe Tour in Kealakekua Bay130from $125.00. Kona Kayaks, 82-6036 Napoopoo Beach Road, Captain Cook, HI 96704, United States 8089877282 KONA KAYAKS IN KEALAKEKUA BAY - KAYAK & SUP RENTALS OPEN 8:00AM - 4:00PM EVERY DAY SOLD MAY 10, 2022. Deluxe Sail & Snorkel to the Captain Cook Monument (From $141.82) Afternoon Sail & Snorkel to the Captain Cook Monument (From $82.73) Big Island Adventure Bundle: 5 Epic Audio Driving Tours (From $29.99) Guided Outrigger Canoe Tour in Kealakekua Bay (From $125.00) See all The Captain Cook Monument experiences on Tripadvisor 4. If you're on the big island, this is an absolute must experience!!! per adult (price varies by group size) Ultimate Circle Island Adventure with Waimea Waterfall. There are restrooms in the park and showers to rinse off the salt water. Captain Cook Time São Paulo Time 11:00 AM Thursday Captain Cook: ↔: 06:00 PM Thursday São Paulo: 12:00 PM Thursday Captain Cook: ↔: 07:00 PM Thursday São Paulo For Sale: 88-1541 Puhala Ave, Captain Cook, HI 96704 ∙ $99,000 ∙ MLS# 663307 ∙ Magical ocean and coastline views from this 1.145 acre lot perched on the hillside overlooking Milolii. Kanu Private Island, opening in the summer of 2019, is only 15 minutes by boat from the mainland, but offers a one-of-a-kind sanctuary Discover private gardens, plunge-pools, and stairs Hopping on a private jet to fly off to a secluded private island was once thought of as a luxury only experienced by the ultra-rich a la Lifestyles of the Rich. Amazing tours, outstanding rentals and guidance with aloha. We rented kayaks to have an adventure across Kealakekua Bay. Kayak rentals, tours, and sales Surf lessons, rentals, and sales, lessons Stand Up Paddle Boards rentals, lessons, tours and sales Snorkel gear rentals and sales Body Board rentals and sales Retails clothing Established in 1996. ![]() In Button City, players will complete quests at the arcade and around town to push the story forward. Players will take on the role of Fenn, a fox who has just moved to town, who will need to team up with some new friends to stop the local arcade from being shut down. Button City launches on August 10 for PC, PS4, PS5, Xbox One, Xbox Series X, and Switch for $19.99 USD.Help friendly animals save the local arcade.īutton City is a narrative adventure game that takes place in an extremely colorful world of the same name. This review is based on a digital Steam code provided by the publisher. The minigames are hit or miss, but it’s not enough to ruin an overall joyful experience. The fascinating characters and hilarious dialogue make the story really endearing, and it’s all bolstered by the game’s art and music. The friends we made along the wayīutton City is a pretty decent second outing from the team at Subliminal Games. It’s even integrated into the story and character interactions, such as when Sorrel is doing yoga to rock music. Music changes depending where in the city you are and is always quite groovy. The music in Button City helps to set the tone for the experience. The use of pastel colors also works to emphasize the sense of coziness that’s constantly present in Button City. The art style is warm and welcoming, a stark contrast to the personas of some of the characters you come across during the story. A city as cute as a buttonĪ lot of the cuteness and charm in Button City also comes from the environment itself. It felt far less interesting and engaging compared to the intense moments experienced in the arcade. I also felt like the game was at its weakest when I was completing quests that required me to go fetch random items. These felt much shallower than Gobabots, with mechanics and controls that felt far from refined or fair. ![]() These minigames range in genres, including a rhythm game and a racing game. Outside of the coveted Gobabots, there are other games in the arcade for players to jump into as they progress through Button City. That said, I did enjoy Gobabots more than some of the other minigames featured. It’s practically a MOBA within a game that you get to play against NPCS, with its own unique sense of style. There’s a lot of Gobabots to play in Button City, and it’s a minigame I quite enjoyed. When Fennel first joins the Fluff Squad, they’re introduced to Gobabots, a popular game in which players collect berries and score by putting them in a blender. In most instances, I was entertained by simply watching NPCs banter back and forth with each other. The characters can be archetypal, but there’s a level of awareness to it that makes it endearing. ![]() The characters in Button City also play off of each other pretty well, thanks to some pretty excellent writing. It’s a game that makes you meet and interact with a bunch of characters, and it’s always a joy. From the over-the-top quirkiness of Lavender the panda to the heavy metal yoga antics of Sorrel the cat, everybody in Button City is bursting with character. On their journey, Fennel meets a lot of animals, all with uniquely distinct personalities. ![]() When it turns out one of these groups, the Fluff Squad, is in desperate need of a fourth member, Fennel is called into action.Ī lot of the charm and appeal in Button City comes from its characters. Fennel then discovers the arcade, which is home to a rivalry between two groups in the town. Filled with other anthropomorphic animals, Fennel is a bit of an outcast, spending all of their time locked away in their room playing video games. A new animal in townīutton City follows the story of Fennel, a young fox that recently moved to the titular town of Button City. With some interesting characters and a cozy art style, it’s hard to walk away from Button City without feeling warm inside. The studio’s latest release, Button City, was revealed back at the Wholesome Games Showcase and once again finds cute animals at the core of its design. Developer Subliminal Games first hit the scene with Sky Pets back in 2015, an arcade game that let players customize animals and use them to collect stars. We, and service providers acting on our behalf may collect “ Personal Information”, which is information that identifies, relates to, describes, is reasonably capable of being associated with, or could reasonably be linked, directly or indirectly, with a particular individual or household. This Privacy Policy applies to information collected from the CAP Site unless different terms are specified in an online or other form or contract we provide you. This privacy policy (“ Privacy Policy”), which is separate from Costco’s privacy policy, describes our policies and practices regarding the collection, use and disclosure of your information as part of the Costco Auto Program and our technology platforms, including, without limitation, our website, mobile application, call center, text and chat communications, customer surveys, interactive features and social media pages (collectively, the “ CAP Site”). CAP respects your right to privacy and your ability to make informed choices about the uses of your information. Affinity Auto Program is an independent company, not an affiliate of Costco Wholesale Corporation (“ Costco”). The Costco Auto Program is operated by Affinity Auto Programs, Inc. The Costco Auto Program’s Commitment to Privacy Costco member must pay sales tax and tax is charged on the purchase amount prior to discount where required.Ĭopyright © 2010 - 2022 Affinity Development Group, Inc., all rightsĬostco is a trademark of Costco Wholesale Corporation Not all Costco Auto Program dealerships currently participate in this benefit. Not applicable to 1) prior services, parts or work 2) items covered by a vehicle’s warranty or insurance policy 3) or at the time of vehicle purchase or lease. It cannot be used toward the purchase of air bags, oil changes, tires, state-mandated vehicle inspections or be combined with other promotions or incentives. Wholesale, Affinity Development Group and its subsidiaries make no implied guarantees or warranties to thisġ15% discount only applies to work done at participating service centers, not Costco Tire Centers. All informationĪnd vehicle data available on this website has been provided by reputable third parties. Actual savings may vary based on vehicle purchased, dealer and location. Certain vehicles may beĮxcluded from the program. Participation fee has been paid by the dealers participating in the Costco Auto Program. All vehiclesĪrranged for sale are subject to availability and a price prearranged with the participating franchised dealer. This acquisition plans to transform the terminal into the preferred hub for COSCO services, where cargo flows will be concentrated.Costco and its affiliates do not sell automobiles or negotiate individual transactions. The relationship between COSCO and the port of Hamburg took a decisive turn in September 2021, when the Chinese company started negotiations with the port of Hamburg to acquire 35 per cent of the shares of the CTT. A few days ago, it was reported that future Italian Prime Minister Giorgia Meloni is contemplating the idea of Italy leaving the Belt and Road Initiative. Germany is not the first country that has recently challenged China’s approach when it comes to the New Silk Road. On the other hand, Axel Mattern, CEO of Port of Hamburg Marketing, claimed that the port of Hamburg is involved in business, not politics and that COSCO’s arrival needs to be viewed as an opportunity. ![]() However, the spokesperson pointed out that rail freight is not significantly damaged by this situation, since there are four other locations in the port where China Railway Express cargo is handled. The spokesperson told that “there will be no information about the concrete remodeling plans for HHLA Container Terminal Tollerort until the transaction is approved”. This means that the city can take important decisions without necessarily consulting with the Federal government.įinalising the transaction is quite a necessary step to carry on projects and works in the port. Hamburg, in fact, has its own parliament and senate. Adding to the dispute is the fact that the city-state of Hamburg is the major stakeholder of HHLA, which operates the port. Recently, COSCO postponed the deadline to finalise operations from September to the end October 2022, instigating the German government’s dismay. ![]() ![]() We aim to please and from start to finish, you’ll know that we take great pride in our work.Our water-fed pole system is the most advanced technology in window cleaning. Read our dozens of reviews from highly satisfied customers all around Los Angeles who have chosen SqueegeePro for all their window cleaning and pressure washing needs and then experience our dedication for yourself. When it comes to price, service, and customer satisfaction, no one knows windows and cleaning like we do.ĭon’t risk inferior window cleaning. We invite you to get estimates from a variety of window cleaners in Los Angeles and surrounding areas, but make sure that one of those estimates comes from SqueegeePro. It’s all possible with your Los Angeles window washers. Lower your energy costs with solar panel cleaning that allows more sun to be absorbed by your panels. Reveal your home’s true beauty with pressure washing that takes years off of your walkways, driveway, patios, and siding. Trust our dedication and attentiveness, as well as our techniques and innovations to deliver a pristine clean that fills your home with natural light in a way no other window cleaners can. It’s time to call in the experts at SqueegeePro and see for yourself why we are the best window cleaners in Los Angeles. If you´re ready to take the next step and enjoy cleaner, more brilliant windows with a shine that adds light to any room, it’s time to put down the spray bottle of vinegar and stop fussing with paper towels. Whether you choose to work with SqueegeePro for a one’time pressure washing of your deck or siding, or you choose to work with us on a regular basis for window cleaning in Los Angeles, we know you´ll be delighted and amazed at the results. We’re happy to provide you with an estimate for the work as well as answer any questions you may have about the process. If you need window cleaning in Los Angeles, or any of our other services including solar panel cleaning or pressure washing of your deck, patio, walkway, driveway or siding, simply give us a call or fill out the free form online and let us know more about what you need. We understand the dangers of working in high places, but that doesn’t mean that we don’t make your higher floor windows any less clean! Trust the experts in Los Angeles window cleaning: Trust SqueegeePro! We are fully licensed, bonded and insured against possible accidents, giving you peace of mind against accidental slips and falls. You’ll want to look for an Los Angeles window cleaner that can handle high places and angles safely. In fact, you may be surprised at just how much light your newly cleaned windows let in after having them cleaned professionally by SqueegeePro! In cleaning the interior of your windows, we can also clean screens and blinds, as these can collect and retain dirt easily. We can also just clean the exterior if you prefer. At SqueegeePro, we can clean the interior and exterior of your windows, as well as window tracks and skylights. When it comes to working with window cleaners in Los Angeles, what should you know before you call for a quote? The truth is, not all window cleaning companies are created equal. Call Squeegee Pro today for a free estimate to get your windows clean no matter how high they might be. Trust the experts in Dana Point window cleaning. We understand the dangers of working in these high risk environments, but that doesn’t mean your higher floor windows are any less clean when the job is done. Our window washers are fully licensed, bonded, and insured against accidental slip and fall incidents. Hiring the right window cleaners in Dana Point also means having the best team of professionals who know how to stay safe when working at high elevations. Anything that can pick up dirt, soot, grime, and muck in and around your windows. These include more than just the interior and exterior of every window in your residential or commercial property, we do window tracks and skylights, window screens and even your window treatments like blinds and shades. That's because we offer a comprehensive menu of window washing services that put the other guys to shame. Our team at Squeegee Pro go the extra mile to ensure 100% customer satisfaction. But not all window companies are created equal. There are plenty of companies out there who want your business. Each template is prefilled with sample data, so that you can see how it. Pricing: Quip’s Starter plan is available at 10 user/month and Plus plan is available at 25 user/month. ![]() These 21 base templates include video walkthroughs, a written guide, and examples so you can. Notion Utopia - Notion templates, dashboards & tools.August bradley notion templates Hellraiser is a 1987 British supernatural horror film written and directed by Clive Barker, and produced by Christopher Figg, based on Barkers 1986 novella The. As noted, Airtable offers a wide variety of useful templates to help you get started. Get your TpT business organized and streamlined with Airtable. Let’s kick things off with one of our new categories: marketing. Verified 3 days ago Url: Go Now Get more: Real Estate All Real Estate. With that in mind, we’ll be highlighting a few of our favorite templates from each category over the next few weeks. We develop each Airtable template with one goal in mind: to distill the collective wisdom and best practices that members of our community, including the 30,000+ organizations already using Airtable, have shared with us so we can save you a little time getting started. Airtable has a wide range of templates for. Both of these project management tools can help your teams keep track of deliverables, but when you need to make a decision, you need a breakdown of both of the features, cost and abilities. ![]() But that doesn’t mean you need to start from scratch every single time! Airtable and Asana are two of the best project management software solutions on the market. We think of Airtable as a set of building blocks that you can use to create the tools you need to work the way you want. Recently, we’ve added whole new categories to the Airtable template gallery, including brand new sections for creative projects, publishing, marketing, product & design, and everyday life. Look for a social media calendar template that allows you to: See an overview of all posts, but also filter those posts by campaign, category, topic, or social platform. Part of our ongoing templates and best practices series.įrom advertising campaigns to growth experiments and brand asset management, here’s a set of templates to streamline operations at every stage in the funnel. "Not saying he shouldn't go at another time BUT WHO goes on that kind of vacation - especially outside the United States - when they are told to stay home AND is $600,000 in debt while crying on Instagram Live for people to pay to watch his documentary? "Credibility? Feldman - after he says he is $600,000 in debt from his documentary - leaves the United States during the current pandemic when people are told to stay home, goes to Jamaica to an adult resort that costs $400-$500 a day for two people to stay. Within a month, he passed away in Las Vegas. Never did he introduce me to Michael, but that didn't matter, I wasn't friends with him for that reason. I sent him $200 that same day, knowing I'd never see it again. "Majestik called me a week after that, told me about Feldman visiting, and the story, and him needing a few dollars. WHO goes to Vegas with no money, anyhow? Feldman said he would send Majestik some funds when he got home. "Corey gave him a story of not having money. "That documentary - from all accounts - should have run maybe $100,000 to $150,000 at most, as it was shot in his home, his friends' homes, and one location, as he went to Corey Haim's gravesite. "He ran 'sex parties' at his home, with his son right there in his bedroom at a young age, charging people hundreds of dollars to come in and 'hang out' with the girls, charging them to use bedrooms, charging them to use the cabana's outside next to his pool, did two GoFundMe fundraisers to fleece his fans and people out of money for his 'security, legal team, and to film a documentary.' ![]() what credibility does he believe he has? "Credibility? Coming from a 'con-man' who's lied for decades about being on drugs, lied to the media, lied to people who met him, etc. NEVER did he dispute what I stated - or the story - until it didn't fit his current narrative, and this was, of course, MANY decades later. We even went on Howard Stern's radio show, and I told the story, HE - Feldman - was right next to me. "My telling of the story has never changed since that day. I took him to 'MEET' her at a public place - The Comedy Store - as I stated, and that was at his instigation via the phone call asking me to drive him there. "To be totally transparent and absolute here, ONLY once did I give him a ride anywhere. Yep, must have really affected his ability to have relations with a member of the opposite sex. "Three marriages, a child, hundreds of female lovers. Now, almost 33 years later, he says anything different - those drugs must really be kicking in. "ANY young man past puberty who has a 'physical happening' voluntarily and mutually agreed to with an older woman of such beauty and kindness is one lucky guy. ![]() "I didn't even have my own place in LA yet! Gotta give him this, he does have an imagination!!! ![]() "I let him use 'my place' so he could have a 'tryst' with Ginger? NOW THAT IS FUNNY! I was staying in Alyssa Milano's FAMILY home at that time my room consisted of a single bed and a desk, which was Alyssa's father's office. Giving Scott Schwartz an opportunity to rebut the rebuttal, he was more than happy to oblige with further comment. Whether the delivery and demeanor on Haim's part are convincing is up to the viewer to decide - and user reaction comments on the video seem to be debating that very behavior. At the 1:09 mark - when asked if the two are still best friends - Feldman can be heard saying, "Always," while Haim responds, "Forever." We were also given the link to this video (below) to support the hypothesis that Corey Haim and Corey Feldman were, indeed, friends. We were also told by Feldman's publicist that - while Scott is currently starring on The Quarantine Bunch with Keith Coogan, Coogan appears in Corey's documentary, and "entirely backs up Corey's story." That should be the most important thing." This is a time when we all really need to come together to change laws and protect children. "I'm not sure who Scott is protecting or why he is doing this, but it's very unfortunate. "At the time, she was also in a relationship with a man. ![]() ![]() native tallied 11 multiple block games in 2006-07, including a season-high four against Denver and three in the NCAA Tournament against Memphis. Williams has proved one of the best shot blockers to wear a North Texas uniform, and already ranks fifth in program history with 68 career blocks. Williams showed his offensive touch with 52 assists - making him the only player in school history and only player in the Sun Belt to rack up over 35 blocks and 50 assists. His 38 blocks on the year ranks sixth in Mean Green history. The junior finished the year ranked fourth in the SBC with 38 blocks - 1.12 per game. Collected six double-doubles, including four in a seven game span in the stretch run of Sun Belt play. The junior ranked third in the conference in field goal percentage at 57.6 percent. Only UALRs Rashad Jones-Jennings - the nations leading rebounder - had more offensive rebounds than Williams in Sun Belt play. One of the Sun Belts most polished big man, Williams was one of only five players in the league to average at least 10 points and seven rebounds per game in 2006-07. Finished third on the team with a scoring average of 9.7 points per game. Tallied four straight double-doubles in the heart of Sun Belt play (averaged 13.5 PPG, 12.0 RPG over that span). Led the team in rebounding and blocked shots as both a junior and a senior. Posted a 19-rebound performance against Indiana State, which is tied for the 15 th best rebounding game in NT history. Was the only player in the Sun Belt to average at least 9.0 PPG, 7.5 RPG and 1.0 BPG. 15 career double-doubles, including seven in 2007-08. Played in 120 career games for the Mean Green, and shot 49.4 percent from the floor for his career. 500 season in all four years of Williams career, making him just the third player in school history to accomplish this feat, and the first since 1954. Blocked 98 career shots, which ranks 3 rd in program history. 691 career rebounds rank 10 th in Mean Green history. Finished his career ranked 24th in school history in career scoring with 909 points. ![]() Don’t forget to write this down if you need it. Note: For some reason, the view angle, the digital zoom, is not saved. Voila! The camera returns to the position you saved before. Then come back to Second Life, return to the sim where you were working on your photo, bring up Cameratools, again, and press the other eye icon, the one with the up arrow under it. Now, go walk the dog, go to that all-so-important office meeting, go to have a drink with your friends, do whatever. The optical zoom, your focus, and the camera angle are all saved. On the Cam Control 1 tab, pressing the eye icon with the down arrow saves your current camera position. Saving your camera positionĬameratools provides you with a variety of ways for controlling your camera, but its most useful feature by far is it allows you to save your camera position! Note: As with Phototools, Cameratools are not available in the Linden viewer. ![]() If you’re using a 3D mouse you can adjust the controls for that here, too. Camera ToolsĬameratools gives you various options for controlling your camera movement, view angle (digital zoom), and a variety of other controls for controlling the way your camera behaves. You can access Cameratools from the Firestorm menu, World – Photo and Video – Cameratools, or from the keyboard – Ctrl+Shift+C. You can actually save your camera position using Cameratools. What if the dog needs to be walked or the boss wants you to actually do real life work – The nerve! – or something else pulls you away from the photo you’ve spent hours setting up?ĭo you have to go back and spend time trying to get the camera make in position, again?įortunately, no. So what happens when you get pulled away from your photo? ![]() Setting up a photo in Second Life can take time, sometimes a lot of time getting the camera angle and focus point just the way you want might take hours (Sometimes it takes me days.). All of these things affect your camera position and your camera view. Last week, I introduced depth of field, optical versus digital zoom, and using Alt+LMB (left mouse button) to set your focus point. Myra Wildmist is back with another SL Photography Tip: ![]() It has been suggested that cerebrospinal fluid (CSF) NfL levels are increased in ALS patients compared to patients with other neurodegenerative diseases, and phosphorylation of Nfs is indicative of the pathogenesis of some neurodegenerative diseases. One of the known factors of the histopathological mechanisms of ALS includes alteration of axonal transport and protein aggregation. Nfs are composed of at least three polypeptide subunits such as neurofilament light chain (NfL, 68 kDa), neurofilament medium chain (NfM, 150 kDa) and neurofilament heavy chain (NfH, 200 kDa). Neurofilament proteins (Nfs) are target in large myelinated neurons. Neurofilament heavy chain proteins might be a promising biomarker in the disease progression of ALS. We also discussed potential biomarkers in ALS, potential compounds for the treatment of ALS, possible uses of stem cell therapy in ALS, and immunotherapy for the treatment of ALS. We discussed several outcomes of these potential neurotrophic factors for the treatments of ALS. Thus, neurotrophic factors have been the focus in clinical trials to restore the deficits of the motoneurons in ALS. However, the pool target of different trophic factors might have neuroprotection for the motoneurons. Riluzole, an inhibitor of glutamate release, is the only compound clinically used in patients suffering from ALS. To the best of our knowledge, there are no potential drugs for the treatments of ALS. Thus, the spatiotemporal organization of the motoneurons makes it difficult to find efficient procedures for the treatment of this disease. Motoneurons are considered a key factor in ALS the survival of these neurons depends on their targets, skeletal muscle and myelinated Schwann cells surrounding the peripheral axons. Another possible primary mechanism could be related to the toxin itself of the mutant SOD1. Unbalanced glutamate uptake may be critical for ALS disease, as a dramatic loss of glutamate transporters has been found in the ALS motor cortex. ![]() There are several hypotheses suggesting that neuronal death may be caused by oxidative stress, a deficit in trophic factors, chronic inflammation, and possibly glutamate-induced excitoxicity ]. The molecular mechanisms of neuronal death are unknown for ALS. Thus, ALS might be caused or induced through several factors, both genetic and environmental. Another cause of ALS includes mutations in valosin-containing protein (VCP) gene and C9ORF72 gene in chromosome 9. There is also evidence that a failure to degrade ubiquitin-dependent protein can lead to the pathogenesis of ALS. There are other forms of ALS that have been found linked to other chromosomes ]. The disease is linked to a genetic defect on chromosome 21q, and chromosome 9q34. It is estimated that 10% of cases are inherited and 20% caused by mutations in superoxide dismutase 1 gene (SOD1), and the remaining cases present mutations of other known and unknown genes. Familial ALS (fALS) is similar to sporadic ALS. Kassis received a post-doctoral research fellowship from American University of Beirut, Beirut, Lebanon a fellowship from the Interdepartmental Program in Cardiothoracic, Pulmonary and Critical Care from Bridgeport/Yale Health System, Bridgeport, CT and a Plastic Surgery Fellowship from Vanderbilt University Medical Center, Nashville, TN.Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder caused by loss of cortical, brainstem and spinal motoneurons ], which occurs in both forms familial and sporadic ALS. He completed his general surgery internship and his residency at Yale University Medical Center, New Haven, CT, where he served as a chief resident in General Surgery. ![]() Kassis received a Bachelor of Science from American University of Beirut, Beirut, Lebanon, and his medical degree from American University as well. His recently published articles include: Comparative Antimicrobial Activity of Commercial Wound-Care Solutions on Bacterial and Fungal Biofilms, Annals of Plastic Surgery Applied Bioengineering in Tissue Reconstruction, Replacement, and Regeneration, Tissue Engineering Characteristics of Patients With Injury Secondary to Smoking on Home Oxygen Therapy Transferred Intubated to a Burn Center, Journal of the American College of Surgeons.ĭr. Kassis’s research interests include migraine surgery, nerve surgery, breast reinnervation, burn surgery, platelet rich plasma/aesthetic surgery, lymphedema, and biofilms. Kassis is certified by the American Board of General Surgery.ĭr. His clinical areas of expertise include cosmetic plastic surgery, acute and reconstructive burn surgery, and chronic headache. Kassis joined our surgical faculty as an Assistant Professor in the Department of Plastic Surgery after completing a Plastic Surgery Fellowship at Vanderbilt University Medical Center, Nashville, TN. |